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If that receptor isn't present, it seems that the HIV virus cannot break into the blood cell. That means it cannot begin the infection that eventually leads to AIDS.

Scientists believe those who have one copy of the CCR5 gene enjoy some resistance against HIV, but not total immunity.

That seems to be the case in about 10 to 15 per cent of those descended from Northern Europeans. Those who inherit two copies of this so-called 'immune gene', one from each parent, seem to have strong immunity to HIV.

That's the case in an estimated 1 per cent of people descended from Northern Europeans. That's the case in an estimated 1 per cent of people descended from Northern Europeans, with Swedes being the most likely candidates.

Scientists say the gene is really a mutation, and that DNA studies suggest it arose in the Middle Ages. Some experts have suggested it spread in response to the Black Plague, while others have pointed to smallpox as more likely.

In the case of Mr Brown, his stem cell donor likely had two copies of the gene. There are a number of hurdles. For one thing, some experts have cautioned that HIV could still be lurking somewhere in Mr Brown's body.

There's also the risk, and difficulty, of doing stem cell transplants, and the relative paucity of donors.

Donating stem cells is a bit more invasive than a standard blood donation, and finding a good fit between donors and recipients isn't easy.

Monitoring: Doctors in California are keeping an eye on Mr Brown's progress, and are impressed by his health.

Cautiously optimistic: Dr. Paul Volberding, who has studied HIV since its discovery, said: 'the Berlin Patient is a fascinating story, it's not one that can be generalized'.

Still, it may soon be possible for scientists to manipulate the receptors on white blood cells to mimic the natural immunity, perhaps by gene therapy that is less invasive than stem cell transplants, or by making genetically engineered stem cells in a lab.

In the meantime, recent studies have shown that healthy patients who take new antiretroviral medications can reduce their risk of getting HIV up to 73 percent.

That's especially being looked at for parts of Africa that are stricken with large numbers of HIV-positive people.

For the estimated 33 million people around the world who are already HIV positive, Mr Brown's story should be encouraging news that scientists are getting closer to a large-scale cure.

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